![]() Because concurrent serious bacterial infection with RSV is uncommon, especially in children ( 6), a timely diagnosis of RSV ARI should diminish unnecessary antibiotic use ( 7, – 9). RSV also produces substantial morbidity and mortality among the elderly and adults with underlying medical conditions ( 4, 5).Īccurate and prompt diagnosis of RSV ARI can have important benefits for patient care. Furthermore, industry-sponsored studies and those that did not use RT-PCR as a reference standard likely overestimated test sensitivity.Īcute respiratory infection (ARI) due to respiratory syncytial virus (RSV) is a leading cause of emergency department (ED) visits and hospitalizations in infants and children ( 1, – 3). Our results suggest that the poor sensitivity of RSV RADTs in adults may preclude their use in this population. Industry-sponsored studies reported significantly higher sensitivity (87% versus 78% P = 0.01). Test sensitivity was poorest using RT-PCR as a reference standard and highest using immunofluorescence (74% versus 88% P < 0.001). Because of this disparity, further subgroup analyses were restricted to pediatric data (63 studies). Sensitivity was higher in children (81% ) than in adults (29% ). ![]() Overall, RSV RADT pooled sensitivity and specificity were 80% (95% confidence interval, 76% to 83%) and 97% (95% CI, 96% to 98%), respectively. ![]() Seventy-one articles met inclusion criteria. Heterogeneity was investigated with prespecified subgroup analyses. Accuracy estimates were pooled using bivariate random-effects regression models. Two reviewers independently extracted data on study characteristics, diagnostic-accuracy estimates, and study quality. Studies reporting sensitivity and specificity data compared to a reference standard (reverse transcriptase PCR, immunofluorescence, or viral culture) were considered. ![]() We searched EMBASE and PubMed for diagnostic-accuracy studies of commercialized RSV RADTs. We performed a systematic review and meta-analysis to evaluate the accuracy of RADTs for diagnosis of RSV infection and to determine factors associated with accuracy estimates. Respiratory syncytial virus (RSV) rapid antigen detection tests (RADT) are extensively used in clinical laboratories. ![]()
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